She also appeared in an episode of Entourage and in the same year, gave her voice to the role of a female golem in The Simpsons episode "Treehouse of Horror XVII".
In 2007, Drescher appeared in the US version of the Australian improvisational comedy series Thank God You're Here.
Francine Joy Drescher (born September 30, 1957) is an American actress and activist.
Drescher graduated from Hillcrest High School in 1975; one of her classmates was comedian Ray Romano.Drescher's first break was a small role as the dancer Connie in the blockbuster movie Saturday Night Fever (1977), in which she delivered the line "So, are you as good in bed as you are on the dance floor? A year later, she began to gain more attention in films such as American Hot Wax (1978) and Summer of Fear (1978).The back-order of season two debuted later in 2012. To promote Happily Divorced, Drescher performed the weddings of three gay couples in New York City using the minister's license she received from the Universal Life Church.Drescher hand-picked the three couples, all of whom were entrants into "Fran Drescher's 'Love Is Love' Gay Marriage Contest" on Facebook, based on the stories the couples submitted about how they met, why their relationship illustrated that "love is love" and why they wanted to be married by her.She also made an appearance in a second-season episode of Who's the Boss? She also had an appearance on Night Court as a woman with dissociative identity disorder who flips from a prude to a sexually minded woman and ends up in a hotel with ADA Dan Fielding.
In 1990, Drescher appeared as Roxanne, in ALF the wife of grown up Brian, who had no clue she was the Mob Boss, in the episode "Future's So Bright I Gotta Wear Shades".
It'll probably be more like The Odd Couple." In 2010, Drescher returned to television with her own daytime talk show, The Fran Drescher Tawk Show.
While the program debuted to strong ratings, it ended its three-week test run to moderate success, resulting in its shelving.
Drescher made her screen debut with a small role in the 1977 blockbuster film Saturday Night Fever, and later appeared in American Hot Wax (1978) and Wes Craven's horror tale Stranger in Our House (1978).
In the 1980s, she gained recognition as a comedic actress in the films Gorp (1980), The Hollywood Knights (1980), Doctor Detroit (1983), This Is Spinal Tap (1984), and UHF (1989) while establishing a television career with guest appearances on several series.
In the 2000s, Drescher made a return to television both with leading and guest roles.